姓名

刘晓娟

性别

女

专业技术职称

教授

学科专业

病原生物学

单  位

南通大学

电子邮箱

lxj@ntu.edu.cn

联系电话（办公）

0513-850519999

个人简历

刘晓娟，女，1975年10月20日出生，江苏如皋人，复旦大学基础医学院生物化学与分子生物学专业博士毕业，现为南通大学医学院病原生物学系教授。本人一直致力于疾病的炎症机制研究，迄今为止以第一作者或者通讯作者发表SCI论文40余篇，以第一发明人获得国家发明专利3项，并转让专利权2项。

教育经历（按时间倒序排序） 

2011/09-2014/07 复旦大学，基础医学院，生物化学与分子生物学，博士，导师：顾建新教授

2001/09-2004/07 南通大学，医学院，免疫学，硕士，导师：钱勣虎教授

1994/09-1999/06 南通医学院，临床医学，学士

工作经历（科研与学术工作经历，按时间倒序排序） 

2020/07-至今南通大学，医学院，病原生物学系，教授

2014/07-2020/08 南通大学，医学院，病原生物学系，副教授

2011/01-2014/06 南通大学，医学院，病原生物学系，讲师

2005/01-2010/12 南通大学，医学院，微生物学与免疫学教研室，讲师

1999/08-2004/12 南通大学，医学院，微生物学与免疫学教研室，助教

研究领域

疾病的炎症机制

代表性成果（论文、专著、专利等）

论文（按时间倒序排序）

[1] Zeng J, Wu M, Zhou Y, Zhu M, Liu X^#. Neutrophil Extracellular Traps (NETs) in Ocular Diseases: Biomolecules. 2022 Oct 8;12(10):1440.

[2] Wang Y, Xie L, Zhu M, Guo Y, Tu Y, Zhou Y, Zeng J, Zhu L, Du S, Wang Z, Zhang Y, Liu X^#, Song E. Shikonin alleviates choroidal neovascularization by inhibiting proangiogenic factor production from infiltrating macrophages. Exp Eye Res. 2021 Dec;213:108823.

[3] Zhou Y, Zeng J, Tu Y, Li L, Du S, Zhu L, Cang X, Lu J, Zhu M, Liu X^#. CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization. Invest Ophthalmol Vis Sci. 2021 Mar 1;62(3):37.

[4] Tu Y, Song E, Wang Z, Ji N, Zhu L, Wang K, Sun H, Zhang Y, Zhu Q, Liu X^#, Zhu M. Melatonin attenuates oxidative stress and inflammation of Müller cells in diabetic retinopathy via activating the Sirt1 pathway. Biomed Pharmacother. 2021 May;137:111274.

[5] Liu X^*, Guo A, Tu Y, Li W, Li L, Liu W, Ju Y, Zhou Y, Sang A, Zhu M. Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization.Cell Death Dis. 2020 Nov 27;11(11):1016.

[6] Liu W, Xu W, Chen Y, Gu L, Sun X, Qu Y, Zhang H, Liu X^#, Huang H. Elevated double-strand break repair protein RAD50 predicts poor prognosis in hepatitis B virus-related hepatocellular carcinoma: A study based on Chinese high-risk cohorts. J Cancer. 2020 Aug 14;11(20):5941-5952.

[7] Wang Y, Liu X*, Zhu L, Li W, Li Z, Lu X, Liu J, Hua W, Zhou Y, Gu Y, Zhu M. PG545 alleviates diabetic retinopathy by promoting retinal Müller cell autophagy to inhibit the inflammatory response. Biochem Biophys Res Commun. 2020 Oct 22;531(4):452-458.

[8] Li W, Liu X^*, Tu Y, Ding D, Yi Q, Sun X, Wang Y, Wang K, Zhu M, Mao J. Dysfunctional Nurr1 promotes high glucose-induced Müller cell activation by up-regulating the NF-κB/NLRP3 inflammasome axis. Neuropeptides. 2020 Aug;82:102057.

[9] Tonello R, Xie W, Lee SH, Wang M, Liu X, Strong JA, Zhang JM, Berta T. Local Sympathectomy Promotes Anti-inflammatory Responses and Relief of Paclitaxel-induced Mechanical and Cold Allodynia in Mice. Anesthesiology. 2020 Jun;132(6):1540-1553.

[10] Tu Y, Zhu M, Wang Z, Wang K, Chen L, Liu W, Shi Q, Zhao Q, Sun Y, Wang X, Song E, Liu X^#. Melatonin inhibits Müller cell activation and pro-inflammatory cytokine production via upregulating the MEG3/miR-204/Sirt1 axis in experimental diabetic retinopathy. J Cell Physiol. 2020 Nov;235(11):8724-8735.

[11] Liu X*, Tonello R, Ling Y, Gao YJ, Berta T. Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1. J Neuroinflammation. 2019 Nov 10;16(1):209.

[12] Liu X*, Zhu M, Ju Y, Li A, Sun X. Autophagy dysfunction in neuropathic pain. Neuropeptides. 2019 Jun;75:41-48.

[13] Shen Y, Liu X*, Shi J, Wu X. Involvement of Nrf2 in myocardial ischemia and reperfusion injury. Int J Biol Macromol. 2019 Mar 15;125:496-502.

[14] Zhu M, Liu X*, Wang Y, Chen L, Wang L, Qin X, Xu J, Li L, Tu Y, Zhou T, Sang A, Song E. YAP via interacting with STAT3 regulates VEGF-induced angiogenesis in human retinal microvascular endothelial cells. Exp Cell Res. 2018 Dec 15;373(1-2):155-163.

[15] Xue P, Liu X*, Shen Y, Ju Y, Lu X, Zhang J, Xu G, Sun Y, Chen J, Gu H, Cui Z, Bao G. E3 Ubiquitin Ligase c-cbl Inhibits Microglia Activation After Chronic Constriction Injury. Neurochem Res. 2018 Aug;43(8):1631-1640.

[16] Liu X*, Li A, Ju Y, Liu W, Shi H, Hu R, Zhou Z, Sun X. β4GalT1 Mediates PPARγ N-Glycosylation to Attenuate Microglia Inflammatory Activation. Inflammation. 2018 Aug;41(4):1424-1436.

[17] Guo W, Liu X*, Li J, Shen Y, Zhou Z, Wang M, Xie Y, Feng X, Wang L, Wu X. Prdx1 alleviates cardiomyocyte apoptosis through ROS-activated MAPK pathway during myocardial ischemia/reperfusion injury. Int J Biol Macromol. 2018 Jun;112:608-615.

[18] Wang B, Liu S, Fan B, Xu X, Chen Y, Lu R, Xu Z, Liu X^#. PKM2 is involved in neuropathic pain by regulating ERK and STAT3 activation in rat spinal cord. J Headache Pain. 2018 Jan 18;19(1):7.

[19] Gu L, Zhao J, Zhang S, Xu W, Ni R, Liu X^#. Runt-related transcription factor 2 (RUNX2) inhibits apoptosis of intestinal epithelial cells in Crohn's disease. Pathol Res Pract. 2018 Feb;214(2):245-252.

[20] Wang B, Fan B, Dai Q, Xu X, Jiang P, Zhu L, Dai H, Yao Z, Xu Z, Liu X^#. Fascin-1 Contributes to Neuropathic Pain by Promoting Inflammation in Rat Spinal Cord. Neurochem Res. 2018 Feb;43(2):287-296.

[21] Liu X*, Huang S, Liu C, Liu X, Shen Y, Cui Z. PPP1CC is associated with astrocyte and microglia proliferation after traumatic spinal cord injury in rats. Pathol Res Pract. 2017 Nov;213(11):1355-1364.

[22] Shao L, Liu X*, Zhu S, Liu C, Gao Y, Xu X. The Role of Smurf1 in Neuronal Necroptosis after Lipopolysaccharide-Induced Neuroinflammation. Cell Mol Neurobiol. 2018 May;38(4):809-816.

[23] Song Y, Liu X*, Feng X, Gu Z, Gu Y, Lian M, Xiao J, Cao P, Zheng K, Gu X, Li D, He P, Wang C.NRP1 Accelerates Odontoblast Differentiation of Dental Pulp Stem Cells Through Classical Wnt/β-Catenin Signaling. Cell Reprogram. 2017 Oct;19(5):324-330.

[24] Chen R, Gong P, Tao T, Gao Y, Shen J, Yan Y, Duan C, Wang J, Liu X^#. O-GlcNAc Glycosylation of nNOS Promotes Neuronal Apoptosis Following Glutamate Excitotoxicity. Cell Mol Neurobiol. 2017 Nov;37(8):1465-1475.

[25] Zhang C, Liu X*, Miao J, Wang S, Wu L, Yan D, Li J, Guo W, Wu X, Shen A. Heat shock protein 70 protects cardiomyocytes through suppressing SUMOylation and nucleus translocation of phosphorylated eukaryotic elongation factor 2 during myocardial ischemia and reperfusion. Apoptosis. 2017 May;22(5):608-625.

[26] Zhu M, Liu X*, Wang S, Miao J, Wu L, Yang X, Wang Y, Kang L, Li W, Cui C, Chen H, Sang A. PKR promotes choroidal neovascularization via upregulating the PI3K/Akt signaling pathway in VEGF expression. Mol Vis. 2016 Dec 2;22:1361-1374.

[27] Liu X*, Yan D, Li Y, Sha X, Wu K, Zhao J, Yang C, Zhang C, Shi J, Wu X. Erythroblast transformation-specific 2 correlates with vascular smooth muscle cell apoptosis in rat heterotopic heart transplantation model. J Thorac Dis. 2016 Aug;8(8):2027-2037.

[28] Liu X*, Zhu M, Yang X, Wang Y, Qin B, Cui C, Chen H, Sang A. Inhibition of RACK1 ameliorates choroidal neovascularization formation in vitro and in vivo. Exp Mol Pathol. 2016 Jun;100(3):451-459.

[29] Liu X, Huang Y, Zhang Y, Li X, Liu C, Huang S, Xu D, Wu Y, Liu X^#. T-cell factor (TCF/LEF1) binding elements (TBEs) of FasL (Fas ligand or CD95 ligand) bind and cluster Fas (CD95) and form complexes with the TCF-4 and b-catenin transcription factors in vitro and in vivo which result in triggering cell death and/or cell activation. Cell Mol Neurobiol. 2016 Aug;36(6):1001-1013.

[30] Zhang Y, Liu X*, Xue H, Liu X, Dai A, Song Y, Ke K, Cao M. Upregulation of PRDM5 Is Associated with Astrocyte Proliferation and Neuronal Apoptosis Caused by Lipopolysaccharide. J Mol Neurosci. 2016 May;59(1):146-157.

[31] Liu X*, Yang X, Zhu R, Dai M, Zhu M, Shen Y, Fang H, Sang A, Chen H. Involvement of Fra-1 in Retinal Ganglion Cell Apoptosis in Rat Light-Induced Retina Damage Model. Cell Mol Neurobiol. 2017 Jan;37(1):83-92.

[32] Liu X*, Zhang C, Qian L, Zhang C, Wu K, Yang C, Yan D, Wu X, Shi J. NF45 inhibits cardiomyocyte apoptosis following myocardial ischemia-reperfusion injury. Pathol Res Pract. 2015 Dec;211(12):955-962.

[33] Lin Y, Xu D, Li X, Liu C, Liu X, Huang S, Huang Y, Liu X^#. Upregulation of Interferon Regulatory Factor 6 Promotes Neuronal Apoptosis After Traumatic Brain Injury in Adult Rats. Cell Mol Neurobiol. 2016 Jan;36(1):27-36.

[34] Shi J, Wu K, Yang X, Yan D, Qian L, Zhang C, Yang C, Zhang C, Wu X, Liu X^#. Nur77 is involved in graft infiltrating T lymphocyte apoptosis in rat cardiac transplantation model. Pathol Res Pract. 2015 Sep;211(9):633-640.

[35] Huang S, Liu X*, Zhang J, Bao G, Xu G, Sun Y, Shen Q, Lian M, Huang Y, Cui Z. Expression of Peroxiredoxin 1 After Traumatic Spinal Cord Injury in Rats. Cell Mol Neurobiol. 2015 Nov;35(8):1217-1226.

[36] Yang X, Chen H, Zhu M, Zhu R, Qin B, Fang H, Dai M, Sang A, Liu X^#. Up-Regulation of PKM2 Relates to Retinal Ganglion Cell Apoptosis After Light-Induced Retinal Damage in Adult Rats. Cell Mol Neurobiol. 2015 Nov;35(8):1175-1186.

[37] Sang A, Yang X, Chen H, Qin B, Zhu M, Dai M, Zhu R, Liu X^#. Upregulation of SYF2 Relates to Retinal Ganglion Cell Apoptosis and Retinal Glia Cell Proliferation After Light-Induced Retinal Damage. J Mol Neurosci. 2015 Jun;56(2):480-490.

[38] Liu X*, Yuan D, Nie X, Shen J, Yan Y, Zhang D, Gu J. BTEB2 prevents neuronal apoptosis via promoting bad phosphorylation in rat intracerebral hemorrhage model. J Mol Neurosci. 2015 Jan;55(1):206-216.

[39] Liu X*, Cheng C, Shao B, Wu X, Ji Y, Lu X, Shen A. LPS-stimulating astrocyte-conditioned medium causes neuronal apoptosis via increasing CDK11(p58) expression in PC12 cells through downregulating AKT pathway. Cell Mol Neurobiol. 2013 Aug;33(6):779-787.

[40] Liu X*, Cheng C, Shao B, Wu X, Ji Y, Lu X, Shen A. The functional interaction between CDK11p58 and β-1,4-galactosyltransferase I involved in astrocyte activation caused by lipopolysaccharide. Inflammation. 2012 Aug;35(4):1365-1377.

[41] Liu X*, Cheng C, Shao B, Wu X, Ji Y, Liu Y, Lu X, Shen A. CDK11(p58) promotes rat astrocyte inflammatory response via activating p38 and JNK pathways induced by lipopolysaccharide. Neurochem Res. 2012 Mar;37(3):563-573.

注：^*第一作者，^#通讯作者。

专利（按时间倒序排序）

[1] 刘晓娟；朱曼辉；孙晓雷；李爱红；郭爱松，MLN4924在制备脉络膜新生血管治疗药物中的应用，2022年05月06日授权，专利号ZL202010468240.X

[2] 刘晓娟；沈爱国；朱曼辉；陈辉，62aa多肽类似物及其载体和应用，2020年03月10日授权，专利号ZL201610351478.8

[3] 刘晓娟；沈爱国；颜大亮；史加海，抗CAV的多肽类似物和对应的cDNA及应用，2018年11月16日授权，专利号ZL201610071300.8