姓 名

张新化

性别

男

专业技术职称

教授

学科专业

人体解剖学

单  位

南通大学

电子邮箱

zhangxinhua@ntu.edu.cn

联系电话（办公）

0513-85051718

个人简历

 江苏省人体解剖会、神经科学会理事，江苏省人体解剖学会神经发育与再生专业委员会委员。2012和2016年江苏省“333人才工程”和2012年南通市“226人才工程”培养对象，获江苏省优秀青年骨干教师、南通市教学名师、文明教工、优秀教育工作者等荣誉称号。2009年博士毕业于中国科学院上海生科院，2012-2014年美国纽约基础研究所访问学者。主持完成国家、省部级科研基金4项。发表研究性论文60余篇，包括Nature、JNS、Biomaterials、JBC等，主、参编学术专著5部，多家杂志通讯审稿人。研究成果获教育部自然科学奖、中华医学科技奖、江苏省科技进步奖、江苏省医学科技奖、南通市科技进步奖等。

研究领域

 神经再生、神经退行性病、干细胞分化及应用

代表性成果（论文、专著、专利等）

1) Zhengye Tan, Wen Li, Xiang Cheng, Qing Zhu, Xinhua Zhang*. Non-Coding RNAs in the Regulation of Hippocampal Neurogenesis and Potential Treatment Targets for Related Disorders. Biomolecules. 2022 Dec 22;13(1):18. doi: 10.3390/biom13010018.

2) Li W, Wang SS, Shan BQ, Qin JB, Zhao HY, Tian ML, He H, Cheng X, Zhang XH*, Jin GH*. miR-103-3p targets Ndel1 to regulate neural stem cell proliferation and differentiation. Neural Regen Res. 2022 Feb;17(2):401-408. doi: 10.4103/1673-5374.317987.

3) Chunhua Wan*, Xiaoqin Yan, Baoying Hu, Xinhua Zhang*. Emerging Roles of the Nervous System in Gastrointestinal Cancer Development. Cancers (Basel). 2022 Jul 30;14(15):3722. doi: 10.3390/cancers14153722.

4) Li W, Shan B, Cheng X, He H, Qin J, Zhao H, Tian M, Zhang X*, Jin G*. circRNA Acbd6 promotes neural stem cell differentiation into cholinergic neurons via the miR-320-5p-Osbpl2 axis. J Biol Chem. 2022;298(4):101828; doi: 10.1016/j.jbc.2022.101828.

5) Li W, Wang S, Shan B, Cheng X, He H, Qin J, Tang Y, Zhao H, Tian M, Zhang X*, Jin G*. CircHECTD1 Regulates Cell Proliferation and Migration by the miR-320-5p/SLC2A1 Axis in Glioblastoma Multiform. Front Oncol. 2021 May 17; 11:666391. doi: 10.3389/fonc.2021.666391.

6) Li W, Wang S, He H, Qin J, Cheng X, Zhao H, Tian M, Zhang X*, Jin G*. Expression and function of Ndel1 during the differentiation of neural stem cells induced by hippocampal exosomesticle. Stem Cell Res Ther. 2021 Jan 9;12(1):51. doi: 10.1186/s13287-020-02119-2.

7) Cheng X, Li W, Zhao R, Li H, Qin J, Tian M, Zhang X*, Jin G*. The role of hippocampus niche exosomes in rat hippocampal neurogenesis after fimbria-fornix transection. J Biol Chem. 2020 Dec 17: 296:100188. doi: 10.1074/jbc.RA120.015561.

8) Guo J, Cheng X, Zhang L, Wang L, Mao Y, Tian G, Xu W, Wu Y, Ma Z, Qin J, Tian M, Jin G, Shi W, Zhang X*. Exploration of the Brn4-regulated genes enhancing adult hippocampal neurogenesis by RNA-sequencing. J Neurosci Res. 2017; 95(10):2071-2079.

9) Zhang L, Wang LM, Chen WW, Ma Z, Han X, Liu CM, Cheng X, Shi W, Guo JJ, Qin JB, Yang XQ, Jin GH, Zhang XH*. Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats. Neural Regen Res. 2017; 12(7):1103-1110.

10) Shi Wei, Huang Chuanjun, Xu Xide, Jin Guohua, Huang RQ, Huang JF, Chen YN, Ju SQ, Wang Y, Shi YW, Qin JB, Zhang YQ, Liu QQ, Wang XB, Zhang Xinhua*, Chen Jian*. Transplantation of RADA16-BDNF peptide scaffold with human umbilical cord mesenchymal stem cells forced with CXCR4 and activated astrocytes for repair of traumatic brain injury. Acta Biomater. 2016 Nov; 45:247-261.

11) Zhang L, Han X, Cheng X, Tan XF, Zhao HY, Zhang XH*. Denervated hippocampus provides a favorable microenvironment for neuronal differentiation of endogenous neural stem cells. Neural Regen Res. 2016 Apr;11(4):597-603.

12) Shao W, Zhang SZ, Tang M, Zhang XH, Zhou Z, Yin YQ, Zhou QB, Huang YY, Liu YJ, Wawrousek E, Chen T, Li SB, Xu M, Zhou JN, Hu G, Zhou JW. Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin.Nature. 2013; 494(7435):90-4.

13) Wei Shi, Dekang Nie, Guohua Jin, Weiwei Chen, Liang Xia, Xiujie Wu, Xing Su, Xide Xu, Lanchun Ni, Xianan Zhang, Xinhua Zhang*, Jian Chen*. BDNF blended chitosan scaffolds for human umbilical cord MSC transplants in traumatic brain injury therapy. Biomaterials. 2012; 33(11):3119-26.

14) Zhang Xinhua, Jin Guohua, Li Wei, Zou Linqing, Shi Jinhong, Qin Jianbing, Tian Meiling, Li Haoming. Ectopic Neurogenesis in the Forebrain Cholinergic System-Related Areas of a Rat Dementia Model. Stem Cells Dev. 2011; 20(9):1627-38.

15) Xinhua Zhang, Zheng Zhou, Dakui Wang, Aiqun Li, Yanqing Yin, Xiaosong Gu, Fei Ding, Xuechu Zhen, Jiawei Zhou. Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling. J Neurosci 2009; 29(24):7766-7775.

16) Xinhua Zhang, Guohua Jin, Lei Wang, Wenzhong Hu, Meiling Tian, Jianbing Qin, Huiwei Huang. Brn-4 is upregulated in the deafferented hippocampus and promotes neuronal differentiation of neural progenitors in vitro. Hippocampus. 2009; 19(2):176-86.

17) 《Hippocampus》：Factors Regulating Neurogenesis in the Adult Dentate Gyrus. InTech, Croatia, 2018. IBSN: 978-953-51-5739-7

18) 《Neural Stem Cell and Therapy》：neurogenesis of adult hippocampus. InTech Press, Croatia, 2012.

19) 《Stem Cells Basics and Clinical Translation》: Stem Cells and Spinal Cord Regeneration. Shanghai Jiao Tong University Press, Shanghai. 2015.

20) 《Hippocampus-cytoarchitecture and disease》InTech Press, Croatia, 2022.