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导师类别 | 博导 | 专业技术职称 | 教授、主任医师 | |||||||
所在学科专业 | 神经外科 | |||||||||
电子邮箱 | chenjian9079@163.com | 联系电话 | ||||||||
任职情况 | 中国医师协会神经外科分会委员,江苏省医学会神经外科分会副主任委员,江苏省中西医结合学会神经外科分会副主任委员,中华医学会神经外科分会创伤学组委员,中华创伤学会神经创伤学组委员。 | |||||||||
主要研究方向 | 1. 临床研究:中枢神经系统肿瘤的微创手术治疗 2. 基础研究:创伤性脑损伤、脑胶质瘤 | |||||||||
个人简历 | 1982.12-1984.09 上海海洋水下工程科学研究院生理学医学研究室 实习研究员 1984.09-1989.01 南通医学院附属医院神经外科 住院医师、助教 1989.01-1995.07 南通医学院附属医院神经外科 主治医师、讲师 1995.07-2001.08 南通医学院附属医院神经外科 副主任医师、副教授 2001.08-2005.08 南通医学院附属医院神经外科 主任医师、副教授 2005.08至今 南通大学附属医院神经外科 主任医师、教授 2001.12至今 南通大学附属医院神经外科 科主任 2006.12至今 南通大学附属医院大外科 副主任 | |||||||||
学术成果 | 1.Decreasing GSH and increasing ROS in chemosensitivity gliomas with IDH1 mutation 7T/7 Tumour Biol. 2015 Feb;36(2):655-62. 2.An IDH1 mutation inhibits growth of glioma cells via GSH depletion and ROS generation 11T/11 Neurol Sci. 2014 Jun;35(6):839-45. 3.Phosphorylation of Mitogen- and Stress-Activated Protein Kinase-1 in Astrocytic Inflammation: A PossibleRole in Inhibiting Production of Inflammatory Cytokines 10T/10 PLoS One. 2013 Dec 11;8(12):e81747 4.PAX3 is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells 12T/12 Brain Res. 2013 Jul 12;1521:68-78 5.The Expression Patterns of Septin-9 After Traumatic Brain Injury in Rat Brain 11T/11 J Mol Neurosci. 2013 Oct;51(2):558-66 6.OCT4 is epigenetically regulated by DNA hypomethylation of promoter and exon in primary gliomas 9T/9 Oncol Rep. 2013 Jul;30(1):201-6 7.Detection of Serum Alu Element Hypomethylation for the Diagnosis and Prognosis of Glioma 1/13 J Mol Neurosci. 2013 Jun;50(2):368-75 8.SCY1-like 1 binding protein 1 (SCYL1-bp1) interacts with p53-induced RING H2 protein (Pirh2) after traumatic brain injury in rats 1/12 J Mol Histol. 2013 Jun;44(3):271-83 9.BDNF blended chitosan scaffolds for human umbilical cord MSC transplants in traumatic brain injury therapy 12T/12 Biomaterials.2012,33(11):3119-26 DOI:10.1016/j.biomaterials.2012.01.009. 10.Tumor cell targeted delivery by specific peptide-modified mesoporous silica nanoparticles. 6T/6 Journal of Materials Chemistry, 2012, 22(29), 14608–14616 DOI: 10.1039/C2JM32398B 11.Giant spinal cord ependymoma with CSF spread 5T/5 Neurology.2012, 25;79(13):1409. DOI: 10.1212/WNL.0b013e31826c1b68 12.Up-regulation of ski-interacting protein in rat brain cortex after traumatic brain injury. 1/8 J Mol Histol.2013 Feb;44(1):1-10 DOI: 10.1007/s10735-012-9444-9 13Different Functions of HIPK2 and CtBP2 in Traumatic Brain Injury. 9T/9 J Mol Neurosci.2013,49;395-408 DOI:10.1007/s12031-012-9906-2 14Transient global cerebral ischemia induces up-regulation of MLTKα in hippocampal CA1 neurons 6T/6 J Mol Histol. 2012 Apr;43(2):187-93 DOI 10.1007/s10735-011-9381-z 15Changes in Pirh2 and p27kip1 expression following traumatic brain injury in adult rats. 10T/10 J Mol Neurosci. 2012 Jan;46(1):184-91. DOI: 10.1007/s12031-011-9572-9 16Prognostic value of free DNA quantification in serum and cerbrospinal fluid in glioma patients.. 9T/9 J Mol Histol. 2012 Mar;46(3):470-5 DOI: 10.1007/s12031-011-9617-0 17The expression pattern of ADP-ribosyltransferase 3 in rat traumatic brain injury. 10T/10 J Mol Histol. 2012 Feb;43(1):37-47. DOI: 10.1007/s10735-011-9366-y 18Clinical significance and prognostic value of PAX3 expression in human glioma. 1/12 J Mol Neurosci. 2012 May;47(1):52-8. DOI: 10.1007/s12031-011-9677-1 | |||||||||
获奖情况 | 1.颞底经小脑幕经岩入路切除岩斜区肿瘤 第一 江苏省卫生厅新技术引进二等奖,2009 2.磁共振弥散张量成像在运动功能区星形胶质细胞瘤手术中的运用 第一 江苏省卫生厅新技术引进二等奖,2010 3.应用3D-CT静脉造影技术辅助手术切除颅内肿瘤 第二 江苏省卫生厅新技术引进二等奖,2012 | |||||||||
主要科研项目 | 1.Triad1/UBE2Q1经泛素-蛋白酶体途径对脑创伤后继发性神经损伤的影响极其网络调节机制(81371367) 国家自然科学基金(面上项目)2014.01-2017.12 负责人 2.颅脑外伤的临床规范化诊疗技术HS2013068 2013年南通市级社会事业科技创新与示范计划专项 2013.10-2016.10 负责人 | |||||||||
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