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| 导师类别 | 博导 | 专业技术职称 | 特聘教授 | |||||||
| 所在学科专业 | 内科学（肾内） | |||||||||
| 电子邮箱 | by5@le.ac.uk | 联系电话 | 81160216 | |||||||
| 任职情况 | 自2009年起任南通大学特聘教授 | |||||||||
| 主要研究方向 | 1. 急慢性肾损伤的机制-炎症、凋亡及免疫调控 2. 肾损伤的基因谱及治疗（精准医学） | |||||||||
| 个人简历 | ？2009年5月至今：南通大学特聘教授 ？2009年3月至今：复旦大学客座教授 Oct 2012-present:Senior Research Scientist, University Hospitals of Leicester; Honorary Senior Lecturer, Infection, Immunity and Inflammation, University of Leicester May 2008-Sep 2012:Senior Research Scientist, University Hospitals of Leicester; Honorary Lecturer, Infection, Immunity and Inflammation, University of Leicester Dec 2004-Apr 2008:Postdoctoral Research Associate, University Hospitals of Leicester; Honorary Lecturer, Cardiovascular Study, University of Leicester Dec 2001-Nov 2004:Non-clinical Lecturer, Infection, Immunity and Inflammation, University of Leicester Aug 2000-Nov 2001:Postdoctoral Research Assistant, Academic Unit of Nephrology Group, University of Sheffield Sep 1996-Jul 1997:Lecturer & Physician in Charge, Nephrology, Affiliated Hospital of Nantong University, China Aug 1995-Aug 1996:Visiting Research Fellow, Academic Unit of Nephrology, University of Sheffield Apr 1994-Nov 1994:Visiting Research Fellow, Institute of Nephrology, University of Beijing, China Sep 1992- Mar 1994:Lecturer & Physician in Charge, Nephrology, Affiliated Hospital of Nantong University, China Sep 1989-Aug 1992:Research Assistant & Residential Physician, Internal Medicine, Affiliated Hospital of Nantong University, China | |||||||||
| 学术成果 | 近5年的学术论文 （IF 59）*: the corresponding author-22 papers /first author-14 papers, IF 111; total IF 169 : 1.Yang C, Hosgood SA, Patel M, Long, YQ, Zhu TY, Nicholson ML, Yang B*. Cyclic Helix B Peptide in Preservation Solution and Autologous Blood Perfusate Ameliorates Ischemia-Reperfusion Injury in Isolated Porcine Kidneys. Transplantation Direct 2015; 1:1-9 2.Yang C, Zhang C, Zhao Z, Zhu T, Yang B*. Fighting against kidney diseases with small interfering RNA: opportunities and challenges. J Transl Med (IF3.9) 2015;13:39 3.Yang C, Zhao T, Zhao Z, Jia Y, Li L, Zhang Y, Song M, Rong R, Xu M, Nicholson ML, Zhu T, Yang B*. Serum Stabilized Naked Caspase-3 siRNA Protects Auto-transplant Kidneys in a Porcine Model. Mol Ther (IF6.2) 2014;22:1817-28 4.Zhao Z, Yang C, Li L, Zhao T, Wang L, Rong R, Yang B*, Xu M, Zhu T. Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto-transplantation model. J Transl Med (IF3.9) 2014;12:53 5.Han J, Zhang L, Chen X, Yang B*, Guo N, Fan Y. Effects of all-trans retinoic acid on signal pathway of cyclooxygenase-2 and Smad3 in transforming growth factor-β-stimulated glomerular mesangial cells. Exp Biol Med (IF2.2) 2014;239:272-83 6.Wu Y, Zhang J, Liu F, Yang C, Zhang Y, Liu A, Shi L, Wu Y, Zhu T, Nicholson ML, Fan Y, Yang B*. Protective effects of HBSP on ischemia reperfusion and cyclosporine a induced renal injury. Clin Dev Immunol (IF2.9) 2013;2013:758159 7.Yang C, Li L, Xue Y, Zhao Z, Zhao T, Jia Y, Rong R, Xu M, Nicholson ML, Zhu T, Yang B*. Innate immunity activation involved in unprotected porcine auto-transplant kidneys preserved by naked caspase-3 siRNA. J Transl Med (IF 3.9) 2013;11:210 8.Yang C, Zhao T, Lin M, Zhao Z, Hu L, Jia Y, Xue Y, Xu M, Tang Q, *Yang B, Rong R, Zhu T. Helix B surface peptide administered after insult of ischemia reperfusion improved renal function, structure and apoptosis through beta common receptor/erythropoietin receptor and PI3K/Akt pathway in a murine model. Exp Biol Med (IF2.2) 2013;238:111-9 9.Zhao T, Yang C, Qiu Y, Xue Y, Zhao Z, Song D, Qiu Y, Ma Z, Yang B, Xu M, Rong R, Zhu T. Comparison of Regulatory T Cells and FoxP3-Positive T-Cell Subsets in the Peripheral Blood of Renal Transplant Recipients With Sirolimus Versus Cyclosporine: A Preliminary Study. Transplant Proc (IF1.0) 2013;45:148-52 10.Yang C, Jia Y, Zhao T, Xue Y, Zhao Z, Zhang J, Wang J, Wang X, Qiu Y, Lin M, Zhu D, Qi G, Qiu Y, Tang Q, Rong R, Xu M, Ni S, Lai B, Nicholson ML, Zhu T, *Yang B. Naked caspase 3 small interfering RNA is effective in cold preservation but not in autotransplantation of porcine kidneys. J Surg Res (IF1.9). 2013;181: 342-354 11.*Yang B, Hosgood SA, Da Z, Harper SJ, Waller HL, Kay MD, Furness PN, Nicholson ML. Biomarkers assessing warm ischemic injury using an isolated porcine kidney hemoreperfusion model. Exp Biol Med (IF2.2) 2012;237:1462-73 12.Jia Y, Zhao Z, Xu M, Zhao T, Qiu Y, Ooi Y, *Yang B, Rong R, Zhu T. Prevention of renal ischemia-reperfusion injury by short hairpin RNA of endothelin A receptor in a rat model. Exp Biol Med (IF2.2). 2012;237:894-902 13.Jiang S, Tang Q, Rong R, Tang L, Xu M, Lu J, Jia Y, Ooi Y, Hou J, Guo J, *Yang B, Zhu T. Mycophenolate mofetil inhibits macrophage infiltration and kidney fibrosis in long-term ischemia-reperfusion injury. Eur J Pharmacol (IF2.5). 2012;688:56-61 14.Zhao T, Yang C, Xue Y, Qiu YY, Hu L, Qiu Y, Wang X, Yang B, Rong R, Xu M, Zhu T. Impact of basiliximab on the proportion of regulatory T cells and their subsets early after renal transplantation: a preliminary report. Transplant Proc (IF1.0). 2012;44:175-8 15.Hu L, Yang C, Zhao T, Xu M, Tang Q, *Yang B, Rong R, Zhu T. Erythropoietin ameliorates renal ischemia and reperfusion injury via inhibiting tubulointerstitial inflammation. J Surg Res (IF1.9) 2012;176:260-6 16.Haylor JL, Harris KP, Nicholson ML, Waller HL, Huang Q, *Yang B. Atorvastatin improving renal ischemia reperfusion injury via direct inhibition of active caspase-3 in rats. Exp Biol Med (IF2.2). 2011;236:755-63 17.*Yang B, Hosgood SA, Bagul A, Waller HL, Nicholson ML. Erythropoietin regulates apoptosis, inflammation and tissue remodelling via caspase-3 and IL-1β in isolated hemoperfused kidneys. Eur J Pharmacol (IF2.7) 2011;660:420-30 18.*Yang B, Elias JE, Bloxham M, Nicholson ML. Synthetic small interfering RNA down-regulates caspase-3 and affects apoptosis, IL-1 β, and viability of porcine proximal tubular cells. J Cell Biochem (IF3.3) 2011;112:1337-47 19.Pawluczyk IZ, Yang B, Patel SR, Saleem MA, Topham PS. Low-level C-reactive protein levels exert cytoprotective actions on human podocytes. Nephrol Dial Transplant (IF3.6). 2011 Aug;26(8):2465-75 20.*Yang B, Hosgood SA, Nicholson ML. Naked small interfering RNA of caspase-3 in preservation solution and autologous blood perfusate protects isolated ischemic porcine kidneys. Transplantation (IF3.8) 2011;91:501-7 Editor’s Pick: http://journals.lww.com/transplantjournal/Pages/ collectiondetails. aspx?TopicalCollectionId=5 专著：siRNA-Induced RNAi Therapy in Acute Kidney Injury, in the book titled "RNA Interference", ISBN 978-953-51-4614-8, accepted for open access publication in intechopen.com，2015年10月 | |||||||||
| 获奖情况 | ？2013: Protective Effects of HBSP on Ischemia-Reperfusion and Cyclosporine A Induced Renal Injury in a 2-week Rat Model, full travel grant, $2500, the International Society of Nephrology ？2013: Serum Stabilized Naked Caspase-3 siRNA Protects Auto-transplant Kidneys in a Porcine Model; and Toll Like Receptor Signaling Pathway Activated and Inflammation Amplified in Naked Caspase-3 siRNA Preserved Auto-transplant Porcine Kidneys, the TTS International Basic Science Mentee-Mentor Travel Award, 2540 Euro, for the 3rd ESOT Basic Science Meeting/13th TTS Basic Science Symposium ？2012: Naked Caspase-3 Small Interfering RNA Was Effective in Cold Preservation of Isolated Porcine Kidneys, but Did not Protect Preserved Kidneys after Auto-Transplantation, the Transplantation Society International Basic Science Mentee-Mentor Travel Award, $3775, the 24th International Congress of the Transplantation Society. | |||||||||
| 主要科研项目 | ？2016-2019: 国自然面上项目（81570677）备解素在肾缺血再灌注损伤及纤维化中的保护作用及机制，PI, 57万, 南通大学附属医院 ？2014-2016: 国自然青年基金（81300564 to Aifen Liu）TRPM7 在肾缺血再灌注损伤及新型促红素衍生肽肾脏保护中的作用和机制研究, Co PI, 23万, 南通大学 ？2012-2015: 国自然面上项目（81170689）小干扰核糖核酸和促红素衍生肽对肾缺血再灌注和环胞素A损伤的长期效应、机制及其基因表达谱的变化 PI, 58万，南通大学附属医院 | |||||||||
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