姓 名 | 解刚才 | 性别 | 男 | 专业技术职称 | 教授 |
学科专业 | 生殖医学（基础医学） | 单 位 | 南通大学医学院 | ||
电子邮箱 | gangcai@ntu.edu.cn | 联系电话（办公） | 86-0513-85051875 | ||
个人简历 | 解刚才，教授、博士研究生导师。南通大学高层次引进人才，江苏省特聘教授。2015年获得中国科学院大学计算生物学博士学位，2008年获得中国科学技术大学生物学学士学位。具有在国外多个高水平研究所、大学访学及博士后深造研究的经历，包括德国柏林马克斯.德尔布吕克分子医学中心、美国哥伦比亚大学医学中心以及费城儿童医院。代表性研究成果发表于《Nature》、《American Journal of Human Genetics》、《Angiogenesis》、《Cell Discovery》等国际知名期刊杂志上，文章总引用率超过1500次。首次发现HERVH表达阳性的人类初始态胚胎干细胞，并揭示了其相关分子调控机理。主持江苏省自然科学基金及国家自然科学基金各一项，以及主持江苏省特聘教授人才基金一项。 | ||||
研究领域 | 基于转录组学大数据的生殖及大脑衰老研究 | ||||
代表性成果（论文、专著、专利等） | 10篇代表性研究成果（# 通讯作者，*共同第一作者） 1. Jichang Wang*, Gangcai Xie*, Singh M, Ghanbarian AT, Raskó T, Szvetnik A, Cai H, Besser D,Prigione A, Fuchs NV, Schumann GG, Chen W, Lorincz MC, Ivics Z, Hurst LD#, Izsvák Z#. Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells. Nature. Dec 2014. IF: 69.504，中科院1区 2. Shi, J.*, K. L. Fok*, P. Dai*, F. Qiao, M. Zhang, H. Liu, M. Sang, M. Ye, Y. Liu, Y. Zhou, C. Wang, F. Sun#, Gangcai Xie#, and H. Chen#. Spatio-Temporal Landscape of Mouse Epididymal Cells and Specific Mitochondria-Rich Segments Defined by Large-Scale Single-Cell Rna-Seq. Cell Discovery. 2021. IF: 38.09，中科院1区 3. Jung Hoon Son*, Gangcai Xie*, Chi Yuan, Lyudmila Ena, Ziran Li, Andrew Goldstein, Lulin Huang, Liwei Wang, Feichen Shen, Hongfang Liu, Karla Mehl, Emily E Groopman, Maddalena Marasa, Krzysztof Kiryluk, Ali G Gharavi, Wendy K Chung, George Hripcsak, Carol Friedman, Chunhua Weng#, Kai Wang#. Deep phenotyping on electronic health records facilitates genetic diagnosis by clinical exomes. The American Journal of Human Genetics. 2018. IF: 11.043，中科院1区 4. Yunwei Shi*, Xuchu Duan*, Guangmin Xu*, Xiaoning Wang, Guanyun Wei, Shikui Dong, Gangcai Xie#, Dong Liu#. A ribosomal DNA-hosted microRNA regulates zebrafish embryonic angiogenesis. Angiogenesis. 2019. IF: 10.658，中科院1区 5. Qian F*, Wei G*, Gao Y*, Wang X*, Gong J, Guo C, Wang X, Zhang X, Zhao J, Wang C, Xu M, Hu Y, Yin G, Kang J, Chai R#, Gangcai Xie#, Liu D#. Single-cell RNA-sequencing of zebrafish hair cells reveals novel genes potentially involved in hearing loss. Cellular and Molecular Life Sciences. 2022 Jun 26;79(7):385. IF: 9.234，中科院1区 6. Peipei Qian*, Jiahui Kang*, Dong Liu#, Gangcai Xie#. Single cell transcriptome sequencing of zebrafish testis revealed novel spermatogenesis marker genes and stronger Leydig-Germ cell paracrine interactions. Frontiers in Genetics. 2022. IF: 4.772，中科院3区 7. Gangcai Xie*; Dong, C*.; Kong, Y.; Zhong, J.F.; Li, M.; Wang, K#. Group Lasso Regularized Deep Learning for Cancer Prognosis from Multi-Omics and Clinical Features. Genes. 2019, 10, 240. IF: 4.141，中科院3区 8. Liu J, Jin T, Ran L, Zhao Z, Zhu R, Gangcai Xie#, Bi X#. Profiling ATM regulated genes in Drosophila at physiological condition and after ionizing radiation. Hereditas. 2022 Oct 21;159(1):41. IF: 2.595，中科院4区 9. Gangcai Xie#; Xu Zhang; Feng Lv; Mengmeng Sang; Hairong Hu; Jinqiu Wang#; Dong Liu# . Nanopore Sequencing and Hi-C Based De Novo Assembly of Trachidermus fasciatus Genome, Genes, 2021, 12(692). IF: 4.141，中科院3区 10. Linsheng Shi*, Changsheng Chen*, Zhenhua Yin*, Guanyun Wei, Gangcai Xie#, Dong Liu#. Systematic profiling of early regulators during tissue regeneration using zebrafish model.Wound Repair and Regeneration. August 2020. IF: 3.401，中科院3区 # 通讯作者，*共同第一作者 | ||||