代表性成果（论文、专著、专利等） | JW Shi#, KL Fok#, PY Dai#, F Qiao, MY Zhang, HG Liu, MM Sang, M Ye, Y Liu, YW Zhou, CN Wang, F Sun*, GC Xie*, H Chen*. Spatio-temporal landscape of mouse epididymal cells and specific mitochondria-rich segments defined by large-scale single-cell RNAseq. Cell Discov 7, 34 (2021). Shi J, Qiao F, Ye M, Jiang T, Liu J, Zhang M, Xie G, Fok KL, Li X, Chen H .CSE1L/CAS regulates cell proliferation through CDK signalling in mouse spermatogenesis. Cell Proliferation. 2022 Nov;55(11):e13334. Chen H* H*, Shi X, Li X, Diao R, Ma Q, Jin J, Qiu Z, Li C, Yu MK, Wang C, Li X,Li F, Chan DYL, Zhao AZ, Cai Z, Sun F, Fok KL*. CD147 deficiency isassociated with impaired sperm motility/acrosome reaction and offers atherapeutic target for asthenozoospermia. Molecular Therapy Nucleic Acids. 2021 Nov 10;26:1374 1386. 4. Ye M, Chen Y, Liu J, Tian J, Wang X, Fok KL, Shi J *, Chen H *. Interferingwith CSE1L/CAS inhibits tumour growth via C3 in triple negative breast cancer. Cell Proliferation. 2022 May;55(5):e13226. Li X, Yuan C, Shi J, Kang H, Chen Y, Duan Y, Jin J, Cheung LP, Li TC, Liu Y,Cui Y, Ruan YC, Jiang X, Cai Z, Chan HC, Ji L, Zeng X*, Liu J*, Chen H* ,Fok KL*. Beta Defensin 19/119 mediates sperm chemotaxis and isassociat ed with idiopathic infertility. Cell Reports Medicine. 2022 Dec 20;3(12):100825. [*共同通讯作者] Choy KHK, Chan SY, Lam W, Jin J, Zheng T, Law TYS, Yu SS, Wang W, Li L,Xie G, Yim HCH, Chen H*, Fok EKL*. The repertoire of testicularextracellular vesicle cargoes and their involvement in intercompartmental communication associated with spermatogenesis. BMC Biology. 2022 Mar 29;20(1):78. [* 共同通讯作者] Jin J, Li X, Ye M, Qia o F, Chen H *, Fok KL*. Defb19 regulates themigration of germ cell and is involved in male fertility. Cell and Bioscience. 2022 Nov 22;12(1):188. [* 共同通讯作者] Ding N, Zhang X, Zhang XD, Jing J, Liu SS, Mu YP, Peng LL, Yan YJ, Xiao GM, Bi XY, Chen H*, Li FH*, Yao B*, Zhao AZ*. Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes. Gut. 2020 Jan 2. pii: gutjnl-2019-319127 [*共同通讯作者]. Wang C, Zhang J, Fok KL, Tsang LL, Ye M, Liu J, Li F, Zhao AZ, Chan HC*, Chen H*. CD147 Induces Epithelial-to-Mesenchymal Transition by Disassembling Cellular Apoptosis Susceptibility Protein/E-Cadherin/β-Catenin Complex in Human Endometriosis. American Journal of Pathology, 2018Apr 6. pii: S0002-9440(17)30969-0. Wang CQ, Jin AH, Huang WQ, Tsang LL, Cai Z, Zhou XP, Chen H*, Chan HC*. Upregulation of Bcl-2 by CD147 through ERK activation results in abnormal cell survival in human endometriosis. Journal of Clinical Endocrinology & Metabolism,2015,100(7):E955-63 [*共同通讯作者] DiaoR#, Fok KL#, Chen H#, Yu MK, Duan YG, Chung CM, Li Z, Wu HW, Zhang H, Ji ZL, Zhen WH, Ng CF, Gui Y, Cai Z*, Chan HC*.Defective human β-defensin-1 underlies male infertility associated with poor sperm motility and genital tract infection. Science Translational Medicine,2014, 6, 249ra108. [# 共同第一作者]. Chen H#, Fok KL#, Jiang X, Jiang J, Chen Z, Gui Y, Chan HC*, Cai Z*. CD147 regulates apoptosis in spermatocytes but not spermatogonia. Human Reproduction,2012, 27(6): 1568-1576. Chen H, Fok KL, Yu S, Jiang J, Chen Z, Gui Y, Cai Z, Chan HC*. CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis. Molecular Human Reproduction, 2011, 17(7):405-14.
参编专著： 《外分泌生理学：基础与临床》第二版，科学出版社，2011年 |
