代表性成果（论文、专著、专利等）

1、Jun Yu(#), Cong Shen(#), Meng Lin(#), Xia Chen(#), Xiuliang Dai, Zhiran Li, Yunhao Wu, Yangbo Fu, Jinxing Lv, Xiaoyan Huang(*), Bo Zheng(*), Fei Sun(*). BMI1 promotes spermatogonial stem cell maintenance by epigenetically repressing Wnt10b/β-catenin signaling. Int J Biol Sci. 2022; 18(7): 2807-2820.（第一作者；IF: 10.75；中科院二区；JCR Q1区）

2、Jun Yu (#, *), Qianwen Zheng (#), Zhiran Li (#), Yunhao Wu (#), Yangbo Fu, Xiaolong Wu, Dengfeng Lin, Cong Shen, Bo Zheng(*), Fei Sun(*). CG6015 controls spermatogonia transit-amplifying divisions by epidermal growth factor receptor signaling in Drosophila testes. Cell Death Dis. 2021 May 14;12(5):491. （第一作者、通讯作者；IF: 9.685；中科院一区Top期刊；JCR Q1区）

3、Jun Yu(#), Yidan Yan(#), Xiaojin Luan(#), Chen Qiao(#), Yuanyuan Liu(#), Dan Zhao, Bing Xie, Qianwen Zheng, Min Wang, Wanyin Chen, Cong Shen, Zeyu He, Xing Hu, Xiaoyan Huang, Hong Li, Qixiang Shao, Xia Chen(*), Bo Zheng(*) and Jie Fang(*). Srlp is crucial for the self-renewal and differentiation of germline stem cells via RpL6 signals in Drosophila testes. Cell Death Dis. 2019 Apr 1; 10 (4): 294. （第一作者；IF: 9.685；中科院一区Top期刊；JCR Q1区）

4、Min Wang, Xia Chen, Yibo Wu, Qianwen Zheng, Wanyin Chen, Yidan Yan, Xiaojin Luan, Cong Shen, Jie Fang(*), Bo Zheng(*), Jun Yu(*). RpS13 controls the homeostasis of germline stem cell niche through Rho1-mediated signals in the Drosophila testis. Cell Prolif. 2020 Sep 8; e12899. （通讯作者；IF: 8.755；中科院一区Top期刊；JCR Q1区）

5、Zhiran Li (#), Yunhao Wu (#), Yangbo Fu (#), Xia Chen (#), Xi Zhao, Xiaolong Wu, Yajuan Lu, Hui He, Cong Shen, Bo Zheng (*), Jun Yu(*), Fei Sun (*). Cyst stem cell lineage eIF5 non-autonomously prevents testicular germ cell tumor formation via eIF1A/eIF2γ mediated pre-initiation complex. Stem Cell Res Ther. 2022 Jul 26;13(1):351. （通讯作者；IF: 8.079；中科院二区；JCR Q1区）

6、Wanyin Chen, Xiaojin Luan, Yidan Yan, Min Wang, Qianwen Zheng, Xia Chen(*), Jun Yu(*), Jie Fang(*). CG8005 Mediates Transit-Amplifying Spermatogonial Divisions via Oxidative Stress in Drosophila Testes. Oxid Med Cell Longev. 2020 Oct 27; 2020: 2846727.（通讯作者；IF: 7.31；中科院二区；JCR Q2区）

7、Qianwen Zheng, Xia Chen, Chen Qiao, Min Wang, Wanyin Chen, Xiaojin Luan, Yidan Yan, Cong Shen, Jie Fang, Xing Hu, Bo Zheng (*), Yibo Wu (*), Jun Yu (*). Somatic CG6015 mediates cyst stem cell maintenance and germline stem cell differentiation via EGFR signaling in Drosophila testes. Cell Death Discov. 2021 Apr 6;7(1):68. （通讯作者；IF: 7.109；中科院二区；JCR Q2区）

8、Jun Yu(#)，Xiang Lan(#)，Xia Chen(#)，Chao Yu，Yiwen Xu，Yujuan Liu，Lingna Xu，Heng-Yu Fan，Chao Tong(*). Protein synthesis and degradation are essential to regulate germline stem cell homeostasis in Drosophila testes. Development. 2016, 143 (16): 2930-2945. （第一作者；IF: 6.862；中科院二区Top期刊；JCR Q1区）

9、Jun Yu (#), Yibo Wu (#), Hong Li (#), Hui Zhou, Cong Shen, Tingting Gao, Meng Lin, Xiuliang Dai, Jian Ou, Meiling Liu, Xiaoyan Huang (*), Bo Zheng (*), Fei Sun (*). BMI1 Drives Steroidogenesis Through Epigenetically Repressing the p38 MAPK Pathway. Front Cell Dev Biol. 2021 Apr 13;9:665089. （第一作者；IF: 6.081；中科院二区；JCR Q1区）

10、Jun Yu(#)(*), Xiaojin Luan(#), Yidan Yan(#), Chen Qiao(#), Yuanyuan Liu(#), Dan Zhao, Bing Xie, Qianwen Zheng, Min Wang, Wanyin Chen, Cong Shen, Zeyu He, Xing Hu, Xiaoyan Huang, Hong Li, Binghai Chen, Bo Zheng(#), Xia Chen(#), and Jie Fang(*). Small ribonucleoprotein particle protein SmD3 governs the homeostasis of germline stem cells and the crosstalk between the spliceosome and ribosome signals in Drosophila. FASEB J. 2019 Jul; 33 (7): 8125-8137. （第一作者、通讯作者；IF: 5.834；中科院二区Top期刊；JCR Q1区）

11、Tingting Gao(#), Meng Lin(#), Binbin Shao(#), Qiao Zhou(#), Yufeng Wang(#), Xia Chen, Dan Zhao, Xiuliang Dai, Cong Shen, Hongbo Cheng, Shenmin Yang, Hong Li, Bo Zheng(*), Xingming Zhong(*), Jun Yu(*), Li Chen(*), Xiaoyan Huang(*). BMI1 promotes steroidogenesis through maintaining redox homeostasis in mouse MLTC-1 and primary Leydig cells. Cell Cycle. 2020 Aug; 19 (15):1884-1898.（通讯作者；IF: 5.173；中科院三区；JCR Q2区）

12、Dan Zhao(#), Cong Shen(#) (*), Tingting Gao(#), Hong Li(#), Yueshuai Guo(#), Feng Li, Chenchen Liu, Yuanyuan Liu, Xia Chen, Xi Zhang, Yangyang Wu, Yi Yu, Meng Lin, Yan Yuan, Xiaofang Chen, Xiaoyan Huang, Shenmin Yang(*), Jun Yu(*), Jun Zhang(*), Bo Zheng(*). Myotubularin related protein 7 is essential for the spermatogonial stem cell homeostasis via PI3K/AKT signaling. Cell Cycle. 2019 Oct;18 (20): 2800-2813. （通讯作者；IF: 5.173；中科院三区；JCR Q2区）

13、Jun Yu(#)，Hao Wu(#)，Yang Wen(#)，Yujuan Liu(#)，Tao Zhou，Bixian Ni，Yuan Lin，Jing Dong，Zuomin Zhou，Zhibin Hu(*)，Xuejiang Guo(*)，Jiahao Sha(*)，Chao Tong(*). Identification of seven genes essential for male fertility through a genome-wide association study of non-obstructive azoospermia and RNA interference-mediated large-scale functional screening in Drosophila. Hum Mol Genet. 2015, 24 (5):1493-1503.（第一作者；IF: 5.121；中科院二区Top期刊；JCR Q1区）

14、Xia Chen(#), Xiaojin Luan(#), Qianwen Zheng(#), Chen Qiao(#), Wanyin Chen, Min Wang, Yidan Yan, Bing Xie, Cong Shen, Zeyu He, Jun Zhang, Mingxi Liu, Xing Hu, Hong Li, Bo Zheng(*), Jie Fang(*) and Jun Yu(*). Precursor RNA processing 3 is required for male fertility, and germline stem cell self-renewal and differentiation via regulating spliceosome function in Drosophila testes. Sci Rep. 2019 Jul 10; 9 (1): 9988.（通讯作者，IF: 4.996；中科院三区；JCR Q1区）

15、Xia Chen (#), Qianwen Zheng (#), Li Ji (#), Yanyan Zhuang (#), Hao Yu, Xinmeng Cheng, Yun Han, Jinxing Lv, Bo Zheng (*), Yanli Zheng (*), Jun Yu (*). Quantitative proteomics and functional analysis identified novel targets for missed abortion. Exp Cell Res. 2022 Aug 15;417(2):113216. （通讯作者；IF: 4.145；中科院三区；JCR Q3区）

16、Meng Lin (#), Jinxing Lv (#), Dan Zhao (#), Siyu Liu, Jinfu Xu, Yangyang Wu, Fuxin Wang, Jun Zhang, Bo Zheng, Cong Shen (*), Xie Guan (*), Jun Yu (*), Xiaoyan Huang (*). MRNIP is essential for meiotic progression and spermatogenesis in mice. Biochem Biophys Res Commun. 2021 Apr 23;550:127-133. （通讯作者；IF: 3.322；中科院三区；JCR Q2区）

17、Jie Fang(#)(*), Xueke Guo(#), Bo Zheng(#), Wei Han(#), Xia Chen(#), Jiawei Zhu(#), Bing Xie, Jiajia Liu, Xiaojin Luan, Yidan Yan, Zeyu He, Hong Li, Chen Qiao, Jun Yu(*). Correlation between NM23 protein overexpression and prognostic value and clinicopathologic features of ovarian cancer: a meta-analysis. Arch Gynecol Obstet. 2018, 297 (2): 449-458. （通讯作者；IF: 2.493；中科院三区；JCR Q3区）

18、Cong Shen(#), Jinfu Xu(#), Qiao Zhou(#), Meng Lin, Jinxing Lv, Xi Zhang, Yangyang Wu, Xia Chen, Jun Yu(*), Xiaoyan Huang(*), Bo Zheng(*). E3 ubiquitin ligase ASB17 is required for spermiation in mice. Transl Androl Urol. 2021 Dec;10(12):4320-4332. (通讯作者；IF: 2.479；中科院四区；JCR Q2区）

19、Zhibin Hu(#)(*)，Zheng Li(#)，Jun Yu(#)，Chao Tong(#)，Yuan Lin(#)，Xuejiang Guo(#)，Feng Lu，Jing Dong，Yankai Xia，Yang Wen，Hao Wu，Honggang Li，Yong Zhu，Ping Ping，Xiangfeng Chen，Juncheng Dai，Yue Jiang，Shandong Pan，Peng Xu，Kailing Luo，Qiang Du，Bing Yao，Ming Liang，Yaoting Gui，Ning Weng，Hui Lu，Zhuqing Wang，Fengbin Zhang，Xiaobin Zhu，Xiaoyu Yang，Zhou Zhang，Han Zhao，Chenliang Xiong，Hongxia Ma，Guangfu Jin，Feng Chen，Jianfeng Xu，Xinru Wang，Zuomin Zhou，Zi-Jiang Chen(*)，Jiayin Liu(*)，Hongbing Shen，Jiahao Sha(*). Association analysis identifies new risk loci for non-obstructive azoospermia in Chinese men. Nat Commun. 2014, 5:3857. （共同第一作者；IF: 17.694；中科院一区Top期刊；JCR Q1区）

20、Bo Zheng(#)(*), Jun Yu(#), Yueshuai Guo(#), Tingting Gao, Cong Shen, Xi Zhang, Hong Li(*), Xiaoyan Huang(*). Cellular nucleic acid-binding protein is vital to testis development and spermatogenesis in mice. Reproduction. 2018 Jul;156 (1): 59-69. （共同第一作者；IF:3.923；中科院三区；JCR Q2区）

21、Xifeng Yin(#), Jun Yu(#), Yang Zhou, Chengyue Wang, Zhimin Jiao, Zhounan Qian, Hao Sun, Binghai Chen(*). Identification of CDK2 as a novel target in treatment of prostate cancer. Future Oncol. 2018, 14 (8): 709-718. （共同第一作者；IF:3.674；中科院三区；JCR Q3区）

22、Cong Shen(#), Ke Zhang(#), Jun Yu(#), Yueshuai Guo(#), Tingting Gao, Yuanyuan Liu, Xi Zhang, Xia Chen, Yi Yu, Hongbo Cheng, Aiyan Zheng, Hong Li(*), Xiaoyan Huang(*), Xufeng Ding(*), Bo Zheng(*). Stromal interaction molecule 1 is required for neonatal testicular development in mice. Biochem Biophys Res Commun. 2018 Oct 12; 504 (4): 909-915.（共同第一作者；IF: 3.322；中科院三区；JCR Q2区）

23、Cong Shen(#), Jun Yu(#), Xi Zhang, ChenChen Liu, YueShuai Guo, JiaWei Zhu, Ke Zhang, Yi Yu,TingTing Gao, ShenMin Yang, Hong Li, Bo Zheng(*), XiaoYan Huang(*). Strawberry Notch 1 (SBNO1) promotes proliferation of spermatogonial stem cells via the noncanonical Wnt pathway in mice. Asian J Androl. 2019;21(4):345-350. （共同第一作者；IF:3.054；中科院三区；JCR Q2区）

24、Hao Wu(#)，Liwei Sun(#)，Yang Wen(#)，Yujuan Liu，Jun Yu，Feiyu Mao，Ya Wang，Chao Tong，Xuejiang Guo，Zhibin Hu，Jiahao Sha，Mingxi Liu(*)，Laixin Xia(*). Major spliceosome defects cause male infertility and are associated with non-obstructive azoospermia in humans. Proc Natl Acad Sci USA. 2016, 113 (15): 4134-4139. （共同作者；IF:12.779；中科院一区Top期刊；JCR Q1区）

25、Meina Yan, Xinxin Yang, Rong Shen, Chengjiang Wu, Hui Wang, Qing Ye, Peifang Yang, Lubin Zhang, Miao Chen, Bing Wan, Qinqin Zhang, Sheng Xia, Xiaodong Lu, Genbao Shao, Xiaoming Zhou, Jun Yu and Qixiang Shao(*). miR-146b promotes cell proliferation and increases chemosensitivity, but attenuates cell migration and invasion via FBXL10 in ovarian cancer. Cell Death Dis. 2018 Nov 8; 9 (11): 1123. （共同作者；IF: 9.685；中科院一区Top期刊；JCR Q1区）

26、Min Wang(#), Juan-Juan Tang(#), Lin-Xiao Wang, Jun Yu, Li Zhang(*), Chen Qiao(*). Hydrogen sulfide enhances adult neurogenesis in a mouse model of Parkinson's disease. Neural Regen Res. 2021 Jul; 16(7): 1353-1358. （共同作者；IF: 6.058；中科院三区；JCR Q2区）

27、Bixian Ni(#)，Yuan Lin(#)，Liangdan Sun(#)，Meng Zhu(#)，Zheng Li，Hui Wang，Jun Yu，Xuejiang Guo，Xianbo Zuo，Jing Dong，Yankai Xia，Yang Wen，Hao Wu，Honggang Li，Yong Zhu，Ping Ping，Xiangfeng Chen，Juncheng Dai，Yue Jiang，Peng Xu，Qiang Du，Bing Yao，Ning Weng，Hui Lu，Zhuqing Wang，Xiaobin Zhu，Xiaoyu Yang，Chenliang Xiong，Hongxia Ma，Guangfu Jin，Jianfeng Xu，Xinru Wang，Zuomin Zhou，Jiayin Liu，Xuejun Zhang，Donald F. Conrad，Zhibin Hu(*)，Jiahao Sha(*). Low-frequency germline variants across 6p22.2-6p21.33 are associated with non-obstructive azoospermia in Han Chinese men. Hum Mol Genet. 2015, 24 (19): 5628-5636.（共同作者；IF: 5.121；中科院二区Top期刊；JCR Q1区）

28、Xia Chen (#), Yanli Zheng (#), Yun Han (#), Hui He (#), Jinxing Lv, Jun Yu, Hong Li, Shunyu Hou (*), Cong Shen (*), Bo Zheng (*). SAT2 regulates Sertoli cell–germline interactions via STIM1‐mediated ROS/WNT/β‐catenin signaling pathway. Cell Biol Int. 2022 Oct;46(10):1704-1713.（共同作者；IF: 4.473；中科院三区；JCR Q3区）

29、Ni Huang(#)，Yang Wen(#)，Xuejiang Guo，Zheng Li，Juncheng Dai，Bixian Ni，Jun Yu，Yuan Lin，Wen Zhou，Bing Yao，Yue Jiang，Jiahao Sha(*)，Donald F. Conrad(*)，Zhibin Hu(*). A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Non-Obstructive Azoospermia in Humans. Biol Reprod. 2015, 93 (3): 61. （共同作者；IF: 4.161；中科院二区；JCR Q1区）

30、Gaigai Wang(#), Yueshuai Guo(#), Tao Zhou(#), Xiaodan Shi(#), Jun Yu, Ye Yang, Yibo Wu, Jing Wang, Mingxi Liu, Xin Chen, Wenjiao Tu, Yan Zeng, Min Jiang, Suying Li, Pan Zhang, Quan Zhou, Bo Zheng, Chunmei Yu, Zuomin Zhou, Xuejiang Guo(*), Jiahao Sha(*). In-depth proteomic analysis of the human sperm reveals complex protein compositions. J Proteomics. 2013 Feb 21;79:114-22. （共同作者；IF:3.855；中科院二区；JCR Q2区）

31、Yangyang Wu (#), Ting Wang (#), Zigao Zhao, Siyu Liu, Cong Shen, Hong Li, Mingxi Liu, Bo Zheng (*), Jun Yu, Xiaoyan Huang (*). Retinoic Acid Induced Protein 14 (Rai14) is dispensable for mouse spermatogenesis. PeerJ. 2021; 9: e10847.（共同作者；IF: 3.061；中科院三区；JCR Q2区）