• 张小宁
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姓 名

张小宁

性别

男

专业技术职称

副教授

学科专业

基础医学-生殖医学

单  位

医学院

电子邮箱

Zhangxn@ntu.edu.cn

联系电话（办公）

183****6136

个人简历

 近5年来，申请人主要从事男性不育相关的研究工作。从临床需求出发，紧密结合基础研究，聚焦外泌体、lncRNA及钙信号在精子发生与精子功能中的调控作用，以期为男性不育相关疾病的诊疗提供新思路与新靶点。曾主持国家级科研项目2项，市厅级项目2项，参与多项国家重大科研项目，目前在研南通市科技局项目1项。已发表论文30余篇，其中第一作者或通讯作者SCI论文18篇，申请发明专利8项，授权项。

学习经历：

2010/09 - 2014/12，兰州大学，动物学，博士（硕博连读）

2006/09 - 2010/06，兰州大学，生物技术，学士

2019/11 - 2020/11，美国国立卫生研究院（NIH），访问学者

工作经历：

2015/01 – 2019/04，南昌大学，生命科学研究院，助理研究员

2019/05–至今,    南通大学，医学院，副教授

研究领域

1. 长链非编码RNA（lncRNA）在精子发生中的作用研究

2. 钙信号失衡与男性不育研究

3. 外泌体在精子功能调控与男性不育中的作用与机制研究

代表性成果（论文、专著、专利等）

  1. 主持课题

  1. 国家自然科学基金-地区基金项目、81760283、弱精症相关lncRNA ASAL1在人成熟精子中的功能与机制研究、2018/01-2021/12、33万元、已结题、主持。

  2. 国家自然科学基金-青年基金、31801238、 lncSR1在STRBP调控精子变形中的作用与机制研究、2019/01-2021/12、25万、已结题、主持。

  3. 南通市科技局项目-人精浆外泌体及其衍生分子在精子功能调控中的作用机制与应用、202206-202512、10万、在研、主持。

  1. 发表论文

  1. Chen Chen#, Bingqian Li#, Rongzu Huang, Shijue Dong, Yang Zhou, Jian Song, Xuhui Zeng* and Xiaoning Zhang*. Involvement of Ca2+ and ROS signals in nickel-impaired human sperm function. Ecotoxicol. Environ. Saf. 2022 Jan; 231 (2022) 113181.

  2. Hang Kang, Chen Chen, Fengxin Gao, Xuhui Zeng, Xiaoning Zhang*. Expression of PPP3CC and not PPP3R2 is associated with asthenozoospermia. J. Mens Health. 2021 Sep; 17(4):183-189.

  3. Dong S, Chen C, Zhang J, Gao Y, Zeng X, Zhang X*. Testicular aging, male fertility and beyond. Front Endocrinol (Lausanne). 2022; 13:1012119.

  4. Zhou Y, Dong S, Chen C, Liu X, Zeng X, Gao Y, Zhang X*. lncRNA 1700101O22Rik and NONMMUG030480.1 Are Not Essential for Spermatogenesis in Mice. Int J Mol Sci. 2022;23(15):8627.

  5. Yang Zhou#, Xiaona Zhang#, Suping Xiong, Xuhui Zeng*, Xiaoning Zhang*. Predicted gene 31453 (Gm31453) and the gene encoding carboxypeptidase A5 (Cpa5) are not essential for spermatogenesis and male fertility in the mouse. Reprod. Fertil. Dev. 2021 Mar 22. doi: 10.1071/RD20284.

  6. Xiaoning Zhang, Wenwen Zhou, Peng Zhang, Fengxin Gao, Xiuling Zhao, Winnie Waichi Shum* and Xuhui Zeng*. Cabs1 Maintains Structural Integrity of Mouse Sperm Flagella during Epididymal Transit of Sperm.Int. J. Mol. Sci. 2021 Jan 11;22(2):E652.

  7. Xiaoning Zhang*, Rongzu Huang, Yang Zhou, Wenwen Zhou and Xuhui Zeng*. IP3R Channels in Male Reproduction.Int. J. Mol. Sci.2020 Dec 2;21(23):9179.

  8. Xiaoning Zhang, Chen Chen, Yuanyuan Zhong, Xuhui Zeng*. lncRNA involved in triptonide-induced cytotoxicity in mouse germ cells. Reprod. Toxicol. 2020 Dec;98:218-224.

  9. Xiaoning Zhang, Hang Kang, Lizhong Peng, Dandan Song, Xin Jiang, Yanting Li, Houyang Chen, Xuhui Zeng*. Pentachlorophenol inhibits CatSper function to compromise progesterone’s action on human sperm.Chemosphere. 2020 Nov;259:127493.

  10. Yangyang Yuan, Xinbao Ding, Yimin Cheng, Hang Kang, Tao Luo, Xiaoning Zhang, Haibin Kuang, Ying Chen, Xuhui Zeng*, Dalei Zhang*. PFOA evokes extracellular Ca2+ influx and compromises progesterone-induced response in human sperm. Chemosphere2020 Feb;241:125074.

  11. Suping Xiong, Dandan Song, Yang Xiang, Yanting Li, Yuanyuan Zhong, Hongjin Li, Peng Zhang, Wenwen Zhou, Xuhui Zeng, Xiaoning Zhang*.Reactive oxygen species, not Ca2+, mediates methotrexate-induced autophagy and apoptosis in spermatocyte cell line.Basic Clin. Pharmacol. Toxicol.2020 Feb;126(2):144-152.

  12. Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*. Dysregulation of lncRNA and CircRNA Expression in Mouse Testes after Exposure to Triptolide. Curr. Drug Metab.2019;20(8):665-673.

  13. Xiaoning Zhang, Peng Zhang, Dandan Song, Suping Xiong, Hongyan Zhang, Jianbo Fu, Fengxin Gao, Houyang Chen and Xuhui Zeng*. Expression profiles and characteristics of human lncRNA in normal and asthenozoospermia sperm.Biol. Reprod.2019 Apr 1;100(4):982-993.

  14. Liping Zheng, Ruichen Luo, Tie Su, Liaoliao Hu, Fengxin Gao, and Xiaoning Zhang*. Differentially Expressed lncRNAs After the Activation of Primordial Follicles in Mouse.Reproductive Sciences. 2019,26:1094-1104.

  15. Dejun Huang*, Xiaoning Zhang, Chen Zhang, Hui Li, Dong Li, Yan Hu, Feng Yang, Yongmei Qi. 2,4-Dichlorophenol induces DNA damage through ROS accumulation and GSH depletion in goldfish Carassius auratus. Environ. Mol. Mutagen.2018 Dec;59(9):798-804.

  16. Xiaoning Zhang, Fengxin Gao, Jianbo Fu, Peng Zhang, Yuqing Wang, Xuhui Zeng*. Systematic identification and characterization of long non-coding RNAs in mouse mature sperm. PLoS ONE, 2017, 12(3): e0173402.

  17. Fengxin Gao#, Peng Zhang#, Hongyan Zhang, Yunhui Zhang, Yunwen Zhang, Qingyun Hao, Xiaoning Zhang*. Dysregulation of long noncoding RNAs in mouse testes and spermatozoa after exposure to cadmium. Biochem. Biophys. Res. Commun. 2017; 484(2017):8-14.

  18. Jianbo Fu, Xiaoning Zhang*, Peng Chen and Yingmei Zhang. Endoplasmic reticulum stress is involved in 2,4-dichlorophenol-induced hepatotoxicity. J Toxicolol Sci. 2016; 41(6):745-756.

  19. Zhidan Niu, Wenya Zhang, Xueyan Gu, Xiaoning Zhang, Yongmei Qi, Yingmei Zhang*. Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells.Environ. Toxicol. Pharmacol. 2016 Jul;45:212-21.

  20. Xiaoning Zhang, Xiaona Zhang, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4-Dichlorophenol induces ER stress-mediated apoptosis via eIF2α dephosphorylation in vitro. Environl Toxicol. 2016.31(2):245-255.

  21. Xue Wei, Yongmei Qi, Xiaoning Zhang, Xueyan Gu, Hui Cai, Jing Yang, and Yingmei Zhang*. ROS act as an upstream signal to mediate Cadmium-induced mitophagy in brain of mouse. Neurotoxicology. 2015;46C: 19-24.

  22. Xue Wei, Yongmei Qi, Xiaoning Zhang, Qian Qiu, Xueyan Gu, Chen Tao, Dejun Huang, Yingmei Zhang. Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway.Toxicol. Mech. Methods. 2014 Oct;24(7):504-11.

  23. Weiwei Li, Xueyan Gu, Xiaoning Zhang, Jinxin Kong, Nan Ding, Yongmei Qi, Yingmei Zhang, Jufang Wang, Dejun Huang*. Cadmium delays non-homologous end joining(NHEJ) repair via inhibition of DNA-PKcs phosphorylation and downregulation of XRCC4 and LigaseIV.Mutat Res.2015;779:112-123.

  24. Xiaoning Zhang, Xiaona Zhang, Zhidan Niu, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4,6-Trichlorophenol cytotoxicity involves oxidative stress, endoplasmic reticulum stress and apoptosis. Int J Toxico. 2014;33(6):532-541.

  25. Xiaoning Zhang, Hui Li, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4- Dichloro -phenol induces global DNA hypermethylation through the increase of S-adenosylmethionine and the upregulation of DNMTs mRNA in the liver of goldfish Carassius auratus. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2014;160:54-59.

  26. Hui Li, Xiaoning Zhang, Qian Qiu, Zhen An, Yongmei Qi, Dejun Huang*, Yingmei Zhang*. 2,4-Dichlorophenol induces apoptosis in primary hepatocytes of grass carp (Ctenopharyngodon idella) through mitochondrial pathway. Aquat. Toxicol.2013,140-141:117-122.

  27. Yingxia Liu, Wenya Zhang, Xiaoning Zhang, Yongmei Qi, Dejun Huang, Yingmei Zhang*. Arsenic trioxide inhibits invasion/migration in SGC-7901 cells by activating the reactive oxygen species-dependent cyclooxygenase-2/matrix metalloproteinase-2 pathway. Expl. Bio. Med. 2011; 236: 592-597.

  28. 彭利忠，张鹏，周雯雯，曾旭辉，张小宁*. 精子特异性蛋白Cabs1 多克隆抗体的制备及多用途验证. 生物技术通报. 2021, 37(3)

  29. 王语晴，高丰鑫，张小宁*. 哺乳动物精浆胞外囊泡及各组分的功能. 中国生物化学与分子生物学报. 2018. 2. 34( 2) : 162～169.

  30. 张小宁，邱倩，李慧，黄德军，张迎梅*. 草鱼细胞内凋亡抑制蛋白多克隆抗体的制备和检测. 中国科技论文在线精品论文. 2013. 9. 17(6): 1651-1656.




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