姓名

周晓荣

性别

男

专业技术职称

教授

学科专业

免疫学

单  位

南通大学医学院

电子邮箱

zhouxiaorong@ntu.edu.cn

联系电话（办公）

0513-85051893

个人简历

   医学博士，教授。现任南通大学医学院免疫学系主任、江苏省微生物免疫学会委员、江苏省免疫学会常务理事。2007年获得上海交通大学医学院免疫学博士学位。2008年至2012年在美国西南医学中分子生物系做博士后研究。2012-2017年任职美国西南医学中心分子生物系讲师。曾主持4项国家自然科学基金项目和多项省市级课题，发表SCI收录论文数十篇。2017年被聘为江苏省特聘教授；2018年被评为江苏省六大高峰-高层次人才；2020年获得南通市优秀教育工作者称号。

研究领域

主要研究方向：①肿瘤免疫治疗：主要探讨肿瘤免疫治疗和靶向治疗过程中发挥关键作用的免疫分子及其调控机制，以及如何通过激活抗原呈递功能来增强抗肿瘤免疫治疗的效果。②肿瘤的靶向治疗：主要研究肺癌和消化道肿瘤中关键的致病基因和分子机制，寻找诊断和治疗的分子标志物和药物靶点。

代表性成果（论文、专著、专利等）

[1] Sijun Chen, Feijing Wu, Jiaxuan Zhang, Jianwei Zhu, Xiaorong Zhou, Xiaofei Zhi. ADRB2 Regulates the Proliferation and Metastasis of Gastrointestinal Stromal Tumor Cells by Enhancing the ETV1-c-KIT Signaling. J Oncol. 2023 Feb 3; 2023:6413796. doi: 10.1155/2023/6413796.

[2] Guiqing Yu, Yiqi Chen, Yan Zhou, Xiaoling Ding, Xiaorong Zhou. Roles of transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation. Frontiers in Cell and Developmental Biology, 2022 Nov 11; 10:1010639. doi: 10.3389/fcell.2022.1010639.

[3] Xiaoling Ding, Xinchen Sun, Huihui Cai, Lei Wu, Ying Liu, Dingjingyu Zhuo, Guiping Yu, Xiaorong Zhou, Engineering macrophages via nanotechnology and genetic manipulation for cancer therapy. Frontiers in Oncology, 2022 January 6; 11: 786913. doi.org/10.3389/fonc.2021.786913

[4] Qiuyun Xu, Weichen Sun, Jie Zhang, Youmin Mei, Jingyin Bao, Shengping Hou, Xiaorong Zhou, Liming Mao. Inflammasome-targeting natural compounds in inflammatory bowel disease: Mechanisms and therapeutic potential. Frontiers in Immunology 2022 Aug 24;13:963291.

[5] Yunhan Wang, Zongying Zhang, Weichen Sun, Jie Zhang, Qiuyun Xu, Xiaorong Zhou, Liming Mao. Ferroptosis in colorectal cancer: Potential mechanisms and effective therapeutic targets. Biomed Pharmacother 2022 Sep;153:113524.

[6] Ying Liu, Lei Wu, Hong Lu, En Wu, Jun Ni, Xiaorong Zhou. Enhancing the therapeutic efficacy of KRAS^G12C inhibitors in lung adenocarcinoma cell models by cotargeting the MAPK pathway or HSP90. Journal of Oncology, 2021, 2721466. doi: 10.1155/2021/2721466

[7] Yu Zhao, Yujiao Cao, Yiqi Chen, Lei Wu, Chenxia Jiang, Hua Huang, Xiaorong Zhou. B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy. Immunology 2021 Nov;164(3):507-523.

[8] Weihan Li, Lei Wu, Hui Jia, Zenghua Lin, Renhao Zhong, Yukun Li, Chenwei Jiang, Shifan Liu, Xiaorong Zhou, Erhao Zhang. The low-complexity domains of the KMT2D protein regulate histone monomethylation transcription to facilitate pancreatic cancer progression. Cell Mol Biol Lett. 2021 Nov 10;26(1):45. doi: 10.1186/s11658-021-00292-7.

[9] Xiaoling Ding, Jie Zhang, Ziqin Feng, Qianru Tang, Xiaorong Zhou. MiR-137-3p Inhibits Colorectal Cancer Cell Migration by Regulating a KDM1A-Dependent Epithelial-Mesenchymal Transition. Dig Dis Sci. 2021 Jul;66(7):2272-2282. doi: 10.1007/s10620-020-06518-6.

[10] Xu Q, Zhang J, Qin T, Bao J, Dong H, Xiaorong Zhou, Hou S, Mao L. The role of the inflammasomes in the pathogenesis of uveitis. Exp Eye Res. 2021 Jul; 208:108618. doi: 10.1016/j.exer.2021.108618.

[11] Mangze Hu, Yu Zhao, Yuejiao Cao, Qianru Tang, Ziqin Feng, Jun Ni, Xiaorong Zhou. DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells. Cancer Sci. 2020 Oct;111(10):3588-3599. doi: 10.1111/cas.14603.

[12] Xiaoling Ding, Xiaoying Wang, Xueting Zhu, Jie Zhang, Yiqin Zhu, Xiaoyi Shao, Xiaorong Zhou. JNK/AP1 Pathway Regulates MYC Expression and BCR Signaling through Ig Enhancers in Burkitt Lymphoma Cells. J cancer. 2020 Jan;11(3): 610–618. 

[13] Yu Zhao, Xiaorong Zhou. Engineering Chimeric Antigen Receptor-Natural Killer Cells for Cancer Immunotherapy. Immunotherapy 2020 Jun;12(9):653-664. doi: 10.2217/imt-2019-0139.

[14] Xiaorong Zhou, Bret M. Evers, Mahesh S. Padanad, James A. Richardson, Emily Stein, Jingfei Zhu, Robert E. Hammer, Kathryn A. O’Donnell. Modulation of mutant Kras^G12D-driven lung tumorigenesis by gain or loss of PCDH7 function. Mol Cancer Res. 2019 Feb;17(2):594-603.

[15] Xiaorong Zhou, Weiwei Xian, Jie Zhang, Yiqing Zhu, Xiaoyi Shao, Yu Han, Yue Qi, Xiaoling Ding, Xiaoying Wang. YY1 Binds to the E3ʹ Enhancer and Inhibits the Expression of the Immunoglobulin Kappa Gene via Epigenetic Modifications. Immunology 2018 Dec, 155(4):491-498. doi: 10.1111/imm.12990.

[16] Xiaorong Zhou, Barrett L. Updegraff, Yabin Guo, Michael Peyton, Luc Girard, Jill Larsen, Xian-Jin Xie, Tae Hyun Hwang, Yunyun Zhou, Yang Xie, Jaime Rodriguez-Canales, Pamela Villalobos, Carmen Behrens, Ignacio I. Wistuba, John D. Minna, Kathryn A. O’Donnell. PROTOCADHERIN 7 acts through SET and PP2A to potentiate MAPK signaling by KRAS and EGFR during lung tumorigenesis. Cancer Res. 2017 Jan; 77(1):187-197.

[17] Zhang J, Xu Q, Sun W, Xiaorong Zhou, Fu D, Mao L. New Insights into the Role of NLRP3 Inflammasome in Pathogenesis and Treatment of Chronic Obstructive Pulmonary Disease. J Inflamm Res. 2021 Aug 26;14:4155-4168. doi: 10.2147/JIR.S324323.

[18] Xu Q, Xiaorong Zhou, Strober W, Mao L. Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease. Molecules. 2021 Mar 19;26(6):1725. doi: 10.3390/molecules26061725.

[19] Barrett L. Updegraff, Xiaorong Zhou, Yabin Guo, Pei-Hsuan Chen, Jessica Sudderth, Carla Rodriguez-Tirado, Luc Girard, John D. Minna, Prashant Mishra, Ralph J. DeBerardinis, Kathryn A. O'Donnell. TMPRSS11B promotes MCT4-mediated lactate export and glycolytic metabolism in cancer cells through cleavage of Basigin. Cell Reports 2018, 20;25(8):2223-2233.e6.

[20] Sung-Kyun Park, Xiaorong Zhou, Kathryn Pendleton, Olga V. Hunter, Jennifer Kohler, Kathryn A O’Donnell and Nicholas K. Conrad A conserved splicing silencer dynamically regulates O-GlcNAc transferase intron retention and O-GlcNAc homeostasis. Cell Reports 2017; 20(5):1088-1099.

[21] Suresh S, Durakoglugil D, Xiaorong Zhou, Zhu B, Comerford SA, Xing C, Xie XJ, York B, O'Donnell KA. SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer. PLoS Genet. 2017;13(3):e1006650.