姓 名

毛立明

性别

男

专业技术职称

教授

学科专业

免疫学

单  位

南通大学医学院

电子邮箱

lmmao@ntu.edu.cn

联系电话（办公）

0513-85051678

个人简历

博士，教授，博士生导师。南通大学高层次引进人才，入选江苏省特聘教授。2009年取得中山大学免疫学博士学位，先后在中国科学院上海巴斯德研究所和美国国立卫生研究院过敏症与传染病研究所（NIH, NIAID）进行研究工作近10年，2020年就职南通大学医学院。长期从事免疫学相关研究，近年来在J Clin Invest，Infect Immun，Protein & Cell等行业权威期刊发表学术论文20余篇。主持国家自然科学基金面上项目、国家自然科学基金青年项目、江苏省自然科学基金面上项目等多项课题。

研究领域

固有免疫、免疫调节、自身免疫病

代表性成果（论文、专著、专利等）

1. Mao L, Kitani A, Hiejima E, Montgomery-Recht K, Zhou W, Fuss IJ, Wiestner A, Strober W#. Bruton tyrosine kinase deficiency augments NLRP3 inflammasome activation and causes IL-1β-mediated colitis. J Clin Invest. 2020 Apr 1;130(4):1793-1807

2. Mao L, Kitani A, Similuk M, Oler AJ, Albenberg L, Kelsen J, Aktay A, Quezado M, Yao M, Montgomery-Recht K, Fuss IJ, Strober W#. Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease. J Clin Invest. 2018 May 1;128(5):1793-1806.

3. Xu Q, Sun W, Zhang J, Mei Y, Bao J, Hou S, Zhou X, Mao L#.Inflammasome-targeting natural compounds in inflammatory bowel disease: Mechanisms and therapeutic potential.Front Immunol. 2022 Aug 24;13:963291.

4. Meng J, Li N, Liu X, Qiao S, Zhou Q, Tan J, Zhang T, Dong Z, Qi X, Kijlstra A, Mao L, Yang P, Hou S.NLRP3 attenuates intraocular inflammation by inhibiting AIM2 mediated pyroptosis through the P-SIK1/SREBF1 pathway.Arthritis Rheumatol. 2022 Dec 18.

5. Mao L, Dhar A, Meng G, Fuss I, Montgomery-Recht K, Yang Z, Xu Q, Kitani A, Strober W.Blau syndrome NOD2 mutations result in loss of NOD2 cross-regulatory function.Front Immunol. 2022 Sep 15;13:988862.

6. Zhang J, Xu Q, Sun W, Zhou X, Fu D, Mao L#. New Insights into the Role of NLRP3 Inflammasome in Pathogenesis and Treatment of Chronic Obstructive Pulmonary Disease. J Inflamm Res. 2021 Aug 26;14:4155-4168

7. Mao L, Kitani A, Strober W and Fuss I*. The Role of NLRP3 and IL-1b in the Pathogenesis of Inflammatory Bowel Disease. Front Immunol. 2018 Nov 5; 9:2566.

8. Xu Q, Zhou X, Strober W, Mao L#. Inflammasome Regulation: Therapeutic Potential for Inflammatory Bowel Disease. Molecules. 2021 Mar 19;26(6):1725. doi: 10.3390/molecules26061725.

9. Xu Q, Zhang J, Qin T, Bao J, Dong H, Zhou X, Hou S, Mao L#. The role of the inflammasomes in the pathogenesis of uveitis.Exp Eye Res. 2021. Jul;208:108618.

10. Li H，Wu S，Mao L，Lei G，Zhang L，Lu A，An L，Yang G，Abliz P#，and Meng G#. Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome, Protein & Cell.2013 Jul; 4(7):529-38.