姓 名

庄乾兴

性别

男

专业技术职称

副教授

学科专业

生理学

单  位

南通大学医学院

电子邮箱

qxzhuang@ntu.edu.cn

联系电话（办公）

158****3226

个人简历

庄乾兴，男，南通大学医学院生理学教研室教授、生理学教研室副主任（主持工作）。主要从事神经生物学和生理学的教学和研究工作，研究领域为运动控制的神经环路及其行为学。主持国家自然科学基金和各类省部级科研基金项目3项，其中包括：国家自然科学基金面上项目1项、江苏省自然科学基金面上项目1项、中央高校基本科研业务费项目1项。已在国内外学术刊物上发表研究论文18篇，综述2篇，发表国际和国内会议论文摘要32篇。

研究领域

运动控制的神经环路及其行为学：

　　动物的运动行为受到来自大脑皮层运动区、脑干和脊髓的等级性控制，不同等级的神经结构内部有存在相对独立而各有分工的平行性关系。动物行为的等级性和平行性控制的基础是对神经元乃至神经环路活动的支配和调节。理解动物运动行为的神经环路机制是系统神经科学的终极挑战之一。我们综合利用免疫组织化学技术、单细胞qPCR技术、单细胞电生理记录、清醒动物在体多通道电生理记录、脑内微透析技术、在体光纤记录、CRISPR/Cas9基因编辑、光遗传/化学遗传操控、神经环路示踪、脑内长时程微量给药技术以及动物行为学研究等技术深入研究神经元乃至神经环路活动与动物运动行为之间的关系。我们的研究目标是从分子-神经元/胶质细胞-神经环路-动物行为学水平阐述动物运动行为的神经机制，进而揭示这些运动行为机制在运动疾病中的作用及功能意义。

代表性成果（论文、专著、专利等）

代表性成果：（#同等贡献）

A：研究论文

[1] Qian-Xing Zhuang, Guang-Ying Li, Bin-Li, Chang-Zheng Zhang, Xiao-Yang Zhang, Hong-Zhao Li, Jian-Jun Wang, Jing-Ning Zhu. Regularizing firing patterns of rat subthalamic neurons ameliorates parkinsonian motor deficits. J Clin Invest, 2018, 128: 5413-5427.

[2] Zeng-Xin Qi, Kang-Li Shen, Jian-Ya Peng, Xiu-Juan Fan, Hui-Wei Huang, Jian-Lan Jiang, Jian-Hua Lu, Xiao-Qin Wang, Xiao-Xia Fang, Liang Chen, Qian-Xing Zhuang*. Histamine bidirectionally regulates the intrinsic excitability of parvalbumin-positive neurons in the lateral globus pallidus and promotes motor behaviour. Br J Pharmacol, 2023, DOI: 10.1111/bph.16010.

[3]Jian-Ya Peng, Kang-Li Shen, Xiu-Juan Fan, Zeng-Xin Qi, Hui-Wei Huang, Jian-Lan Jiang, Jian-Hua Lu, Xiao-Qin Wang, Xiao-Xia Fang, Wang-Rui Yuan, Qiao-Xuan Deng, Shu Chen, Liang Chen, Qian-Xing Zhuang*. Receptor and Ionic Mechanism of Histamine on Mouse Dorsolateral Striatal Neurons. Mol Neurobiol, 2023, 60: 183-202.

[4] Qian-Xing Zhuang, Han-Ting Xu, Xu-Juan Lu, Bin Li, Wing-Ho Yung, Jian-Jun Wang, Jing-Ning Zhu. Histamine excites striatal dopamine D1 and D2 receptor-expressing neurons via postsynaptic H1 and H2 receptors. Mol Neurobiol, 2018, 55:8059-8070.

[5] Xiao-Yang Zhang#, Shi-Yu Peng#, Li-Ping Shen#, Qian-Xing Zhuang#, Bin Li, Shu-Tao Xie, Qian-Xiao Li, Ming-Run Shi, Tian-Yu Ma, Qipeng Zhang, Jian-Jun Wang, Jing-Ning Zhu.Targeting presynaptic H3 heteroreceptor in nucleus accumbens to improve anxiety and obsessive-compulsive-like behaviors. Proc Natl Acad Sci U S A, 2020, www.pnas.org/cgi/doi/10.1073/pnas.2008456117.

[6] Yi Wang#, Zhang-Peng Chen#, Qian-Xing Zhuang#, Xiao-Yang Zhang, Hong-Zhao Li, Jian-Jun Wang, Jing-Ning Zhu. Role of corticotropin-releasing factor in cerebellar motor control and ataxia. Curr Biol, 2017, 27:2661-2669.

[7] Guang-Ying Li#; Qian-Xing Zhuang#; Xiao-Yang Zhang; Jian-Jun Wang; Jing-Ning Zhu. Ionic Mechanisms Underlying the Excitatory Effect of Orexin on Rat Subthalamic Nucleus Neurons. Front Cell Neurosci, 2019, 13(153).

[8] Guan-Yi Wu#, Qian-Xing Zhuang#, Xiao-Yang Zhang, Hong-Zhao Li, Jian-Jun Wang, Jing-Ning Zhu. Facilitation of spinal α-motoneuron excitability by histamine and the underlying ionic mechanisms. Acta Physiologica Sinica, 2019, 71(6): 809-823.

[9] Bin Li#, Qian-Xing Zhuang#, He-Ren Gao, Jian-Jun Wang, Jing-Ning Zhu. Medial cerebellar nucleus projects to feeding-related neurons in the ventromedial hypothalamic nucleus in rats. Brain Struct Funct, 2017, 222:957-971.

[10] Jun Zhang#, Qian-Xing Zhuang#, Bin Li, Guan-Yi Wu, Wing-Ho Yung, Jing-Ning Zhu, Jian-Jun Wang. Selective Modulation of Histaminergic Inputs on Projection Neurons of Cerebellum Rapidly Promotes Motor Coordination via HCN Channels. Mol Neurobiol, 2016, 53:1386-1401.

[11] He-Ren Gao#, Qian-Xing Zhuang#, Bin Li, Hong-Zhao Li, Zhang-Peng Chen, Jian-Jun Wang, Jing-Ning Zhu. (2016). Corticotropin releasing factor excites neurons of posterior hypothalamic nucleus to produce tachycardia in rats. Sci rep, 2016, doi: 10.1038/srep20206.6.

[12] He-Ren Gao#, Qian-Xing Zhuang#, Yong-Xiao Zhang, Zhang-Peng Chen, Bin Li, Xiao-Yang Zhang, Yi-Ting Zhong, Jian-Jun Wang, Jing-Ning Zhu. Orexin Directly Enhances the Excitability of Globus Pallidus Internus Neurons in Rat by Co-activating OX1 and OX2 Receptors. Neurosci Bull. 2017, 33:365-372.

[13] Shi-Yu Peng#, Qian-Xing Zhuang#, Yong-Xiao Zhang, Xiao-Yang Zhang, Jian-Jun Wang, Jing-Ning Zhu. Excitatory effect of norepinephrine on neurons in the inferior vestibular nucleus and the underlying receptor mechanism. J Neurosci Res, 2016, 94(8): 736-748.

[14] Xiao-Yang Zhang#, Lei Yu#, Qian-Xing Zhuang#, Shi-Yu Peng, Jing-Ning Zhu, Jian-Jun Wang. Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats. Br J Pharmacol, 2013, 170:156-169.

[15] Chang-Zheng Zhang#, Qian-Xing Zhuang#, Ye-Cheng He, Guang-Ying Li, Jing-Ning Zhu, Jian-Jun Wang. 5-HT2A receptor-mediated excitation on cerebellar fastigial nucleus neurons and promotion of motor behaviors in rats. Pflugers Arch - Eur J Physiol, 2013, 466:1259-1271.

[16] Song-Hua Ma, Qian-Xing Zhuang, Wei-Xing Shen, Yu-Ping Peng, Yi-Hua Qiu. Interleukin-6 reduces NMDAR-mediated cytosolic Ca²⁺ overload and neuronal death via JAK/CaN signaling. Cell calcium, 2015, 58:286-295.

[17] Xiao-Yang Zhang, Lei Yu, Qian-Xing Zhuang, Jun Zhang, Jing-Ning Zhu, Jian-Jun Wang. Hypothalamic histaminergic and orexinergic modulation on cerebellar and vestibular motor control. Cerebellum, 2013, 12:294-296.

[18] Lei Yu, Xiao-Yang Zhang, Zhang-Peng Chen, Qian-Xing Zhuang, Jing-Ning Zhu, Jian-Jun Wang. Orexin excites rat inferior vestibular nuclear neurons via co-activation of OX1 and OX2 receptors. J Neural Transm, 2014, 122(6):747-755.

[19] Qian-Xing Zhuang, Yong-Hui Wu, Guan-Yi Wu, Jing-Ning Zhu, Jian-Jun Wang. Histamine excites rat superiorvestibular nuclear neurons via postsynaptic H1 and H2 receptors in vitro. NeuroSignals, 2013, 21:174-183.

[20] Guan-Yi Wu, Xiao-Hu Han, Qian-Xing Zhuang, Jun Zhang, Wing-Ho Yung, Ying-Shing Chan, Jing-Ning Zhu, Jian-Jun Wang. Excitatory effect of histamine on rat spinal motoneurons by activation of both H1 and H2 receptors in vitro. J  Neurosci Res, 2012, 90:132-142.

B：综述

[1] Xiao-Yang Zhang, Lei Yu, Qian-Xing Zhuang, Jing-Ning Zhu, Jian-Jun Wang. Central functions of the orexinergic system. Neurosci Bull, 2013, 29:355-365.

[2] Guang-Ying Li#, Qian-Xing Zhuang#, Bin Li, Jian-Jun Wang, Jing-Ning Zhu. Subthalamic nucleus: from circuits, functions to a deep brain stimulation target for the treatment of Parkinson's disease. Acta Physiologica Sinica, 2017, 69(5): 611-622.